Article
Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Jul 2011
Lill Christina M, Abel Olubunmi, Bertram Lars, Al-Chalabi Ammar
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous disorder that shows a characteristic dichotomy of familial forms typically displaying Mendelian inheritance patterns, and sporadic ALS showing no or less obvious familial aggregation. While the former is caused by rare, highly penetrant, and pathogenic mutations, risk for sporadic ALS is probably the result of the combined effects of common...
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