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Article

BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38

5 Dec 2007

Abstract excerpt

Osterix, a zinc-finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. Because no bone formation occurs in Osterix null mice, Osterix is thought to be an essential regulator of osteoblast differentiation. We report that bone morphogenetic protein-2 (BMP-2) induces an increase in Osterix expression, which is mediated through a homeodomain sequence located in...

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PMID: 18056716
DOI: 10.1074/jbc.m704724200

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BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38PMID 18056716Read ↗

BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2Semantic proximity Read ↗

BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional NetworkSemantic proximity Read ↗

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The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cellsSemantic proximity Read ↗

Transcriptional Regulation of OsteoblastsSemantic proximity Read ↗

Genetic and molecular control of osterix in skeletal formation.Semantic proximity Read ↗

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone FormationSemantic proximity Read ↗

Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signalingSemantic proximity Read ↗

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone FormationSemantic proximity Read ↗

Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast-Specific ExpressionSemantic proximity Read ↗

Dlx5 regulates chondrocyte differentiation at multiple stages.Semantic proximity Read ↗

Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis role of DLX2 and DLX5 transcription factorsSemantic proximity Read ↗

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