Article
The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels.
Haematologica - 1 Dec 2007
Percy Melanie J, Scott Linda M, Erber Wendy N, Harrison Claire N, Reilly John T, Jones Frank G C, Green Anthony R, McMullin Mary Frances
Abstract excerpt
BACKGROUND AND OBJECTIVES: Idiopathic erythrocytosis (IE) is characterized by erythrocytosis in the absence of megakaryocytic or granulocytic hyperplasia, and is associated with variable serum erythropoietin (Epo) levels. Most patients with IE lack the JAK2 V617F mutation that occurs in the majority of polycythemia vera patients. Four novel JAK2 mutant alleles have recently been described in patients with...
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