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Genetics and prospective therapeutic targets for Sjögren-Larsson Syndrome

25 Feb 2016

Abstract excerpt

INTRODUCTION: , which codes for fatty aldehyde dehydrogenase (FALDH) and results in abnormal metabolism of long-chain aliphatic aldehydes and alcohols. The potential disease mechanisms leading to symptoms include 1) accumulation of toxic fatty aldehydes that form covalent adducts with lipids and membrane proteins; 2) physical disruption of multi-lamellar membranes in skin and brain; 3) abnormal activation of the...

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PMID: 27547594
DOI: 10.1517/21678707.2016.1154453

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