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Article

Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity.

Journal of enzyme inhibition and medicinal chemistry - 1 Oct 2007

Chevreuil Francis, Landreau Anne, Séraphin Denis, Larcher Gérald, Mallet Sabine, Bouchara Jean-Philippe, Richomme Pascal

Abstract excerpt

New 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3-(isoxazol-5-yl)propan-2-ols and 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3-(4,5-dihydroisoxazol-5-yl)propan-2-ols were synthesized by 1,3-dipolar cycloaddition between homopropargylic or homoallylic alcohols and in-situ generated nitrile oxide. Their antifungal activity was evaluated against Candida albicans, C. glabrata, Aspergillus fumigatus and an...

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Identifiers

PMID: 18035824
DOI: 10.1080/14756360701425279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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