Article
Differential collagen I gene expression in fetal fibroblasts.
Journal of pediatric surgery - 1 Jul 1997
Gallivan K, Alman B A, Moriarty K P, Pajerski M E, O'Donnell C, Crombleholme T M
Abstract excerpt
PURPOSE: Fetal wound healing is characterized by the regeneration of normal dermis and the absence of scar. Transforming growth factor beta-1 (TGF-beta1) is a ubiquitous cytokine with potent fibrogenic effects in both postnatal and fetal wounds. Supplementing fetal wounds with TGF-beta1 results in increased fibrosis consisting primarily of collagen I. We hypothesized that the lack of scar formation in fetal...
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