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Article

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration.

Journal of cellular biochemistry - 1 Mar 2008

Wei Wei-Chun, Hsu Yu-Chih, Chiu Wen-Tai, Wang Chau-Zen, Wu Ching-Ming, Wang Yang-Kao, Shen Meng-Ru, Tang Ming-Jer

Abstract excerpt

Previous study demonstrated that low substratum rigidity down-regulates focal adhesion proteins. In this study we found that cells cultured on collagen gel exhibited higher migration capacity than those cultured on collagen gel-coated dishes. Low rigidity of collagen gel induced delayed but persistent phosphorylation of ERK1/2. Inhibition of collagen gel-induced ERK1/2 phosphorylation by MEK inhibitors and ERK2...

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Source

Identifiers

PMID: 18027879
DOI: 10.1002/jcb.21482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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