Article
Manipulation of hedgehog signaling in Xenopus by means of embryo microinjection and application of chemical inhibitors.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Hollemann Thomas, Tadjuidje Emmanuel, Koebernick Katja, Pieler Tomas
Abstract excerpt
Xenopus embryos provide a powerful model system to investigate the complex molecular mechanisms, which are controlled by or control the activity of the Hedgehog (Hh) signaling pathway. The use of synthetic mRNA or antisense oligonucleotide (morpholino) microinjection into blastomeres of early embryos or by simply treating the embryos with small organic inhibitors, has already led to an idea of the network in...
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