Article
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2008
Byrd James Brian, Touzin Karine, Sile Saba, Gainer James V, Yu Chang, Nadeau John, Adam Albert, Brown Nancy J
Abstract excerpt
Angioedema is a potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals. Studies indicate that amino-terminal degradation of these peptides, by aminopeptidase P and dipeptidyl peptidase IV, may be impaired in individuals with...
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