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Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells

1 Nov 2007

Abstract excerpt

Previously, we showed that down-regulation of claudin-10 (CLDN-10) in hepatocellular carcinoma is associated with prolonged disease-free survival after curative surgery. Claudins are important tight junction components. Increasing evidence shows that claudins are involved in cancer progression but each member of claudins is specifically expressed in a variety of malignancies. The biological role of CLDN-10 in...

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PMID: 18025272
DOI: 10.1158/1535-7163.mct-07-0453

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