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Article

Elk with a long incubation prion disease phenotype have a unique PrPd profile.

Neuroreport - 3 Dec 2007

O'Rourke Katherine I, Spraker Terry R, Zhuang Dongyue, Greenlee Justin J, Gidlewski Thomas E, Hamir Amir N

Abstract excerpt

The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease susceptibility, incubation time, clinical presentation, neuropathology, and/or PrP biochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Wasting Disease, Chronic

Source

Identifiers

PMID: 18007190
DOI: 10.1097/WNR.0b013e3282f1ca2f

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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