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Article

CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice.

Neuroreport - 3 Dec 2007

Oishi Katsutaka, Ohkura Naoki, Sei Hiroyoshi, Matsuda Juzo, Ishida Norio

Abstract excerpt

Kaolin-induced writhing reaction is a simple and convenient model of bradykinin-induced pain for assessment of analgesic actions. In this study, we demonstrated that the number of kaolin-induced writhing reaction was fluctuated in a circadian manner that peaked at the end of the resting period (dusk) and reduced during the active (dark) period in mice. Circadian rhythm of the writhing intensity was completely...

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Source

Identifiers

PMID: 18007188
DOI: 10.1097/WNR.0b013e3282f1ca00

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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