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Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation

12 Mar 2008

Abstract excerpt

Toxoplasma gondii is an obligate intracellular parasite that causes severe disease in humans. It is able to infect all nucleated mammalian cells leading to lifelong persistence of the parasite in the host. Here, we studied the effect of T. gondii infection on host cell proliferation and explored the molecular mechanisms involved in host cell cycle progression. We found that T. gondii induced G1/S transition in...

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PMID: 18005238
DOI: 10.1111/j.1462-5822.2007.01093.x

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