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Infection with Toxoplasma gondii results in dysregulation of the host cell cycle

31 Jan 2008

Abstract excerpt

Mammalian cells infected with Toxoplasma gondii are characterized by a profound reprogramming of gene expression. We examined whether such transcriptional responses were linked to changes in the cell cycle of the host. Human foreskin fibroblasts (HFFs) in the G(0)/G(1) phase of the cell cycle were infected with T. gondii and FACS analysis of DNA content was performed. Cell cycle profiles revealed a promotion into...

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PMID: 18182087
DOI: 10.1111/j.1462-5822.2008.01117.x

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