Article
SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines.
Cytogenetic and genome research - 1 Jan 2007
Melcher R, Al-Taie O, Kudlich T, Hartmann E, Maisch S, Steinlein C, Schmid M, Rosenwald A, Menzel T, Scheppach W, Luhrs H
Abstract excerpt
In this study nine colorectal cancer cell lines were analysed by 10K SNP-arrays and spectral karyotyping (SKY). Complex chromosomal alterations and breakpoints of deleted or translocated fragments found by SKY could further be characterized by SNP-array analysis. Interestingly many monoallelic regions identified by SNP-array analysis display no copy number alterations, representing uniparental disomy (UPD). It...
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