Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.

International journal of cancer - 10 Feb 2005

Yuan Yunfei, Liu Hongji, Sahin Aysegul, Dai Jia Le

Abstract excerpt

The gene product of spleen tyrosine kinase (SYK) has been implicated in the suppression of breast cancer invasion. We previously reported that SYK expression is lost in a subset of breast cancer; primarily by methylation-mediated gene silencing. In our study, we explored the possibility of using a DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (AZA), to suppress breast cancer cell invasion by restoring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Carcinoma, Ductal
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to DNA Modification Methylases

Share to Enzyme Precursors

Share to Stilbenes

Share to Syk Kinase

Source

Identifiers

PMID: 15455373
DOI: 10.1002/ijc.20628

Genes

SYK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.PMID 15455373Read ↗

Transcription Repressor Activity of Spleen Tyrosine Kinase Mediates Breast Tumor SuppressionSemantic proximity Read ↗

Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma.Semantic proximity Read ↗

Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular CarcinomaSemantic proximity Read ↗

DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.Semantic proximity Read ↗

Genomic and expression profiling identifies the B‐cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphomaSemantic proximity Read ↗

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasivenessSemantic proximity Read ↗

Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated HerpesvirusSemantic proximity Read ↗

Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell LymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.