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Article

Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment.

PLoS neglected tropical diseases - 30 Aug 2007

Bourguinat Catherine, Pion Sébastien D S, Kamgno Joseph, Gardon Jacques, Duke Brian O L, Boussinesq Michel, Prichard Roger K

Abstract excerpt

BACKGROUND: Onchocerca volvulus is the causative agent of onchocerciasis, or "river blindness". Ivermectin has been used for mass treatment of onchocerciasis for up to 18 years, and recently there have been reports of poor parasitological responses to the drug. Should ivermectin resistance be developing, it would have a genetic basis. We monitored genetic changes in parasites obtained from the same patients...

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Identifiers

PMID: 17989786
DOI: 10.1371/journal.pntd.0000072
PMCID: PMC2041821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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