Article
Single nucleotide polymorphisms in β-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: possible indication of resistance selection.
Molecular and biochemical parasitology - 1 Sept 2012
Nana-Djeunga Hugues, Bourguinat Catherine, Pion Sébastien D S, Kamgno Joseph, Gardon Jacques, Njiokou Flobert, Boussinesq Michel, Prichard Roger K
Abstract excerpt
The control of onchocerciasis or river blindness by mass treatment of the population with ivermectin (IVM) has been a great success until now, so that in certain foci its elimination has become feasible. However, after more than 20 years of repeated IVM mass treatment, the disease still persists in many endemic countries. Sub-optimal responses and genetic changes have been reported in Onchocerca volvulus...
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