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Article

Replicative aging down‐regulates the myogenic regulatory factors in human myoblasts

19 Feb 2008

Abstract excerpt

BACKGROUND INFORMATION: Aging of human skeletal muscle results in a decline in muscle mass and force, and excessive turnover of muscle fibres, such as in muscular dystrophies, further increases this decline. Although it has been shown in rodents, by cross-age transplantation of whole muscles, that the environment plays an important role in this process, the implication of proliferating aging of the muscle...

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Share to Chromosomal and Genetic Variations
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

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PMID: 17988214
DOI: 10.1042/bc20070085

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