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Article

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Nucleic acids research - 1 Jan 2007

Passos João F, Saretzki Gabriele, von Zglinicki Thomas

Abstract excerpt

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear DNA damage or to uncapped telomeres. In addition to a direct role of nuclear DNA double-strand breaks as inducer of a DNA damage response, two more subtle types of DNA damage induced by physiological levels of reactive oxygen...

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Source

Open in PubMed Open full text

Identifiers

PMID: 17986462
DOI: 10.1093/nar/gkm893
PMCID: PMC2190715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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