Article
Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells.
Cancer letters - 18 Jan 2008
Singh Ajay P, Bafna Sangeeta, Chaudhary Kunal, Venkatraman Ganesh, Smith Lynette, Eudy James D, Johansson Sonny L, Lin Ming-Fong, Batra Surinder K
Abstract excerpt
Previously, we have developed a unique in vitro LNCaP cell model, which includes androgen-dependent (LNCaP-C33), androgen-independent (LNCaP-C81) and an intermediate phenotype (LNCaP-C51) cell lines resembling the stages of prostate cancer progression to hormone independence. This model is advantageous in overcoming the heterogeneity associated with the prostate cancer up to a certain extent. We characterized and...
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