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Article

Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy

1 Oct 2005

Abstract excerpt

PURPOSE: After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent samples from primary and metastatic sites. EXPERIMENTAL DESIGN: We compared the gene expression profiles of 10 androgen-independent primary...

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PMID: 16203770
DOI: 10.1158/1078-0432.ccr-05-0585

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