Article
Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2008
Halperin Julia, Devi Y Sangeeta, Devi Sangeeta Y, Elizur Shai, Stocco Carlos, Shehu Aurora, Rebourcet Diane, Unterman Terry G, Leslie Nancy D, Le Jamie, Binart Nadine, Gibori Geula
Abstract excerpt
Prolactin (PRL) is a hormone with over 300 biological activities. Although the signaling pathway downstream of the long form of its receptor (RL) has been well characterized, little is known about PRL actions upon activation of the short form (RS). Here, we show that mice expressing only RS exhibit an ovarian phenotype of accelerated follicular recruitment followed by massive follicular death leading to premature...
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