Article
Description of two new HLA-C alleles in a black South African population.
Tissue antigens - 1 Jan 2008
Minevich G, Kuhn L, Polistena C, Nuara J, Winchester R
Abstract excerpt
Two new HLA-C alleles, Cw*0333 and Cw*0217, were identified in a Black South African population. HLA-Cw*0333 differs from Cw*030201 by an A-->G substitution at nucleotide 323, yielding an unusual missense substitution of Cys for the conserved Tyr-84 at the antigen cleft terminus. Molecular modeling suggests that this alters the predicted interactions of this critical residue with the opposite alpha(2)-helix, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
