Article
Filaggrin null alleles are not associated with hand eczema or contact allergy.
The British journal of dermatology - 1 Dec 2007
Lerbaek A, Bisgaard H, Agner T, Ohm Kyvik K, Palmer C N A, Menné T
Abstract excerpt
BACKGROUND: The filaggrin protein is a key component of stratum corneum and homo- or heterozygotes for the filaggrin variant alleles R501X and 2282del4 have varying degrees of impaired skin barrier. The variant alleles have repeatedly been shown to be associated with atopic dermatitis. Any possible association with hand eczema or contact allergy are unexplored. OBJECTIVES: To explore associations between the...
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