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Article

A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes.

FEBS letters - 27 Nov 2007

Kaneko Masayuki, Yasui Saori, Niinuma Yoshifumi, Arai Kiho, Omura Tomohiro, Okuma Yasunobu, Nomura Yasuyuki

Abstract excerpt

Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1...

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Source

Identifiers

PMID: 17967421
DOI: 10.1016/j.febslet.2007.10.033

Genes

ATF6
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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