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Article

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients.

Blood - 1 Mar 2008

Bacher Ulrike, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten, Schnittger Susanne

Abstract excerpt

We characterized the mutational status of the FLT3 tyrosine kinase domain (FLT3-TLD) in 3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of 3082 (4.8%) patients. Similar to the FLT3 juxtamembrane domain mutations (FLT3-LM), there was a high correlation of FLT3-TKD mutations with normal karyotype (88 of 1472; 6.0%). FLT3-TKD mutations were most frequent in the AML FAB subtypes M5b...

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Share to fms-Like Tyrosine Kinase 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17965322
DOI: 10.1182/blood-2007-05-091215

Genes

FLT3
NPM1
EFS
NRAS
PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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