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Article

Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases.

American journal of medical genetics. Part A - 15 Dec 2007

Riley Bridget M, Murray Jeffrey C

Abstract excerpt

Non-syndromic cleft lip and palate (NS CLP) is a complex birth defect resulting from multiple genetic and environmental factors. We have previously reported the sequencing of the coding region of genes in the fibroblast growth factor (FGF) signaling pathway, in which missense and non-sense mutations contribute to approximately 5%-6% NS CLP cases. In this article we report the sequencing of conserved non-coding...

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Identifiers

PMID: 17963255
DOI: 10.1002/ajmg.a.31965
PMCID: PMC2680818

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