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[Research progress in regulatory variants in non-coding regions in non-syndromic cleft lip with or without cleft palate].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology - 9 Jan 2026

Tang W W, Shi B, Jia Z L

Abstract excerpt

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenital craniofacial malformations, characterized by significant genetic heterogeneity and polygenic features. Historically, genetic studies of NSCL/P have primarily focused on coding region variants. However, only approximately 2% of the human genome consists of coding sequences, with the majority of variants located in...

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Cleft Lip
Cleft Palate
Genetic Variation
Genome-Wide Association Study
Regulatory Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41469019
DOI: 10.3760/cma.j.cn112144-20250604-00205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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