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Article

Impaired FGF signaling contributes to cleft lip and palate.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Riley Bridget M, Mansilla M Adela, Ma Jinghong, Daack-Hirsch Sandra, Maher Brion S, Raffensperger Lisa M, Russo Erilynn T, Vieira Alexandre R, Dodé Catherine, Mohammadi Moosa, Marazita Mary L, Murray Jeffrey C

Abstract excerpt

Nonsyndromic cleft lip and palate (NS CLP) is a complex birth defect resulting from a combination of genetic and environmental factors. Several members of the FGF and FGFR families are expressed during craniofacial development and can rarely harbor mutations that result in human clefting syndrome...

Read the complete abstract on PubMed

Topics

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibroblast Growth Factors

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Share to Sequence Homology, Amino Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 17360555
DOI: 10.1073/pnas.0607956104
PMCID: PMC1810508

Genes

FGFR1
FGF8
FGFR2
FGF10
FGF18
FGF3
FGF7
FGFR3
FGF2
FGF4
FGF9
NUDT6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17360555-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired FGF signaling contributes to cleft lip and palate.PMID 17360555Read ↗

Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases.Semantic proximity Read ↗

The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate.Semantic proximity Read ↗

Studies of genes in the FGF signaling pathway and oral clefts with or without dental anomalies.Semantic proximity Read ↗

Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts.Semantic proximity Read ↗

Development of the lip and palate: FGF signalling.Semantic proximity Read ↗

A heterozygous nonsense variant in FGF8 causes autosomal dominant cleft lip and palate by impairing ERK–ETV4 signalingSemantic proximity Read ↗

Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate.Semantic proximity Read ↗

A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.Semantic proximity Read ↗

Novel Protein-Altering Variants in Cleft Genes Transmitted in Families With NSCL±P.Semantic proximity Read ↗

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.Semantic proximity Read ↗

Rare variants in FAT3 as possible contributors to non-syndromic orofacial cleft risk.Semantic proximity Read ↗

Molecular pathology of the fibroblast growth factor family.Semantic proximity Read ↗

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