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Article

Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes.

Vaccine - 2 Jan 2004

Cassetti M Cristina, McElhiney Sue P, Shahabi Vafa, Pullen Jeffrey K, Le Poole I Caroline, Eiben Gretchen L, Smith Larry R, Kast W Martin

Abstract excerpt

An effective vaccine for treating human papillomavirus (HPV)-associated malignancies such as cervical cancer should elicit strong T cell-mediated immunity (CMI) against the E6 and/or E7 proteins necessary for the malignant state. We have developed Venezuelan equine encephalitis (VEE) virus replicon particle (VRP) vaccines encoding the HPV16 E6 and E7 genes and tested their immunogenicity and antitumor efficacy....

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Source

Identifiers

PMID: 14670335
DOI: 10.1016/j.vaccine.2003.07.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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