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Article

Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16

1 Sept 1991

Abstract excerpt

There is strong evidence implicating human papillomavirus type 16 (HPV16) in the genesis of human genital cancer. Viral DNA has been identified in invasive carcinoma of the uterine cervix and in cell lines derived from cervical carcinomas. These sequences are actively transcribed, and translation products corresponding to the early (E)-region genes have been identified. The most abundant viral protein is the E7...

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PMID: 1714516
DOI: 10.1128/jvi.65.9.4681-4690.1991

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Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16PMID 1714516Read ↗

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Design, Immune Responses and Anti-Tumor Potential of an HPV16 E6E7 Multi-Epitope VaccineSemantic proximity Read ↗

The E7 Open Reading Frame Acts in cis and in trans To Mediate Differentiation-Dependent Activities in the Human Papillomavirus Type 16 Life CycleSemantic proximity Read ↗

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.Semantic proximity Read ↗

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsSemantic proximity Read ↗

Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16‐induced tumorsSemantic proximity Read ↗

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other propertiesSemantic proximity Read ↗

Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease.Semantic proximity Read ↗

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