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Article

FCRL3 -169CT functional polymorphism in type 1 diabetes and autoimmunity traits.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2008

Duchatelet Sabine, Caillat-Zucman Sophie, Dubois-Laforgue Danièle, Blanc Hervé, Timsit José, Julier Cécile

Abstract excerpt

A functional variant located in the promoter region of the Fc receptor like 3 gene (FCRL3, -169CT variant) has been recently shown to be associated with several autoimmune diseases in the Japanese population. Following the concept of shared genetic determinants between autoimmune diseases, we tested this variant for association to Type 1 diabetes (T1D) and T1D-related phenotypes in two independent settings: a...

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Source

Identifiers

PMID: 17961971
DOI: 10.1016/j.biopha.2007.09.003

Genes

FCRL3
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

FCRL3 -169CT functional polymorphism in type 1 diabetes and autoimmunity traits.PMID 17961971Read ↗

The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases.Semantic proximity Read ↗

Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association.Semantic proximity Read ↗

The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans.Semantic proximity Read ↗

Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis.Semantic proximity Read ↗

Fc receptor-like 3 -169 C/T polymorphism and RA susceptibility: a meta-analysis.Semantic proximity Read ↗

The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: an updated meta-analysis.Semantic proximity Read ↗

A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.Semantic proximity Read ↗

Association between Fc receptor-like 3 C169T polymorphism and risk of systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?Semantic proximity Read ↗

Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.Semantic proximity Read ↗

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.Semantic proximity Read ↗

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