Article
FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?
Journal of neuroimmunology - 1 Sept 2007
Martínez Alfonso, Mas Ana, de Las Heras Virginia, Bartolomé Manuel, Arroyo Rafael, Fernández-Arquero Miguel, de la Concha Emilio G, Urcelay Elena
Abstract excerpt
BACKGROUND AND AIMS: A functional promoter polymorphism in the FcRL3 gene, -169 T/C, has been shown to regulate gene expression and to play a role in several autoimmune diseases. We aimed at testing for the first time whether this gene was involved in multiple sclerosis (MS) pathogenesis. METHODS: Case-control study performed with 400 Spanish MS patients and 508 healthy subjects. Genotyping of -169 T/C and -110...
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