Article
Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study.
BMC neurology - 25 Oct 2007
Cole John W, Naj Adam C, O'Connell Jeffrey R, Stine Oscar C, Sorkin John D, Wozniak Marcella A, Stern Barney J, Yepes Manuel, Lawrence Daniel A, Reinhart Laurie J, Strickland Dudley K, Mitchell Braxton D, Kittner Steven J
Abstract excerpt
BACKGROUND: Neuroserpin, primarily localized to CNS neurons, inhibits the adverse effects of tissue-type plasminogen activator (tPA) on the neurovascular unit and has neuroprotective effects in animal models of ischemic stroke. We sought to evaluate the association of neuroserpin polymorphisms with risk for ischemic stroke among young women. METHODS: A population-based case-control study of stroke among women...
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