A Detailed Histologic and Molecular Assessment of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma.

doi:10.1016/j.modpat.2023.100329

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Article

A Detailed Histologic and Molecular Assessment of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2023

Chou Angela, Qiu Min Ru, Crayton Henry, Wang Bin, Ahadi Mahsa S, Turchini John, Clarkson Adele, Sioson Loretta, Sheen Amy, Singh Nisha, Clifton-Bligh Roderick J, Robinson Bruce G, Gild Matti L, Tsang Venessa, Leong David, Sidhu Stanley B, Sywak Mark, Delbridge Leigh, Aniss Ahmad, Wright Dale, Graf Nicole, Kumar Amit, Rathi Vivek, Benitez-Aguirre Paul, Glover Anthony R, Gill Anthony J

Abstract excerpt

Diffuse sclerosing variant papillary thyroid carcinoma (DS-PTC) is characterized clinically by a predilection for children and young adults, bulky neck nodes, and pulmonary metastases. Previous studies have suggested infrequent BRAFV600E mutation but common RET gene rearrangements. Using strict criteria, we studied 43 DS-PTCs (1.9% of unselected PTCs in our unit). Seventy-nine percent harbored pathogenic gene...

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PMID: 37716505
DOI: 10.1016/j.modpat.2023.100329

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