Article
Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms.
The Journal of pathology - 1 Dec 2007
Kern J S, Herz C, Haan E, Moore D, Nottelmann S, von Lilien T, Greiner P, Schmitt-Graeff A, Opitz O G, Bruckner-Tuderman L, Has C
Abstract excerpt
Kindlin-1 is an epithelium-specific phosphoprotein and focal adhesion adaptor component. Mutations in the corresponding gene (KIND1) cause Kindler syndrome (KS), which is manifested by skin blistering, poikiloderma, photosensitivity and carcinogenesis. Some patients also exhibit gastrointestinal symptoms, but it has remained unclear whether these represent a feature of Kindler syndrome or a coincidence. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.