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Article

Postgenomic up-regulation of CCL3L1 expression in HTLV-2-infected persons curtails HIV-1 replication.

Blood - 1 Mar 2007

Pilotti Elisabetta, Elviri Lisa, Vicenzi Elisa, Bertazzoni Umberto, Re Maria Carla, Allibardi Sonia, Poli Guido, Casoli Claudio

Abstract excerpt

Leukocytes of persons coinfected with HTLV-2 and HIV-1 secrete chemokines that prevent CCR5-dependent (R5) HIV-1 infection of CD4+ T cells and macrophages, with HTLV-2-induced MIP-1alpha as dominant HIV-1 inhibitory molecule. Two nonallelic genes code for CCL3 and CCL3L1 isoforms of MIP-1alpha, and the population-specific copy number of CCL3L1 exerts a profound effect on HIV-1 susceptibility and disease...

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Source

Identifiers

PMID: 17062725
DOI: 10.1182/blood-2006-07-036046

Genes

CCL3
CCR5
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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