Article
Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2008
Mayan Haim, Attar-Herzberg Dana, Shaharabany Miriam, Holtzman Eliezer J, Farfel Zvi
Abstract excerpt
BACKGROUND: Familial hyperkalaemia and hypertension (FHH), also termed pseudohypoaldosteronism type II, is a rare monogenic form of hypertension caused by mutations in the WNK1 or WNK4 kinases. In vitro expression of WNK4 reduces surface abundance and activity of coexpressed NaCl cotransporter (NCCT). This effect is lost in disease-producing WNK4 mutants. In two mice models of FHH, one expressing two extra copies...
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