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Article

Familial hyperkalemia and hypertension: pathogenetic insights based on lithium clearance.

The Journal of clinical endocrinology and metabolism - 1 Aug 2009

Mayan Haim, Melnikov Semyon, Novikov Ilya, Holtzman Eliezer J, Farfel Zvi

Abstract excerpt

CONTEXT: Familial hyperkalemia and hypertension (FHHt) is caused by mutations in WNK kinases. Its pathogenesis is not completely understood. OBJECTIVE: Our objective was to investigate the mechanism of hypercalciuria in FHHt. DESIGN AND SETTING: We conducted a study of a large family with FHHt and WNK4 Q565E mutation and of control subjects at a referral medical center. SUBJECTS: Forty-six members of a family...

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Topics

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Share to Hypercalciuria
Share to Hyperkalemia
Share to Lithium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Clearance Rate

Share to Potassium

Share to Receptors, Drug

Share to Solute Carrier Family 12, Member 3

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Source

Identifiers

PMID: 19491230
DOI: 10.1210/jc.2008-2572

Genes

WNK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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