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Article

Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus.

The Journal of biological chemistry - 25 Jan 2008

Nagata Makiko, Kaito Chikara, Sekimizu Kazuhisa

Abstract excerpt

We previously identified the cvfA gene (SA1129) as a novel virulence regulator in Staphylococcus aureus using the silkworm infection model. The cvfA gene, which is conserved among various pathogenic bacteria, contributes to the expression of the agr locus, a global virulence regulator that controls the expression of genes encoding various exoproteins, such as hemolysin. CvfA protein has a transmembrane domain, an...

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PMID: 17951247
DOI: 10.1074/jbc.M705309200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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