Article
Silkworm pathogenic bacteria infection model for identification of novel virulence genes.
Molecular microbiology - 1 May 2005
Kaito Chikara, Kurokawa Kenji, Matsumoto Yasuhiko, Terao Yutaka, Kawabata Shigetada, Hamada Shigeyuki, Sekimizu Kazuhisa
Abstract excerpt
Silkworms are killed by injection of pathogenic bacteria, such as Staphylococcus aureus and Streptococcus pyogenes, into the haemolymph. Gene disruption mutants of S. aureus whose open reading frames were previously uncharacterized and that are conserved among bacteria were examined for their virulence in silkworms. Of these 100 genes, three genes named cvfA, cvfB, and cvfC were required for full virulence of S....
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