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Article

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.

The EMBO journal - 14 Nov 2007

Tsodikov Oleg V, Ivanov Dmitri, Orelli Barbara, Staresincic Lidija, Shoshani Ilana, Oberman Robert, Schärer Orlando D, Wagner Gerhard, Ellenberger Tom

Abstract excerpt

The nucleotide excision repair (NER) pathway corrects DNA damage caused by sunlight, environmental mutagens and certain antitumor agents. This multistep DNA repair reaction operates by the sequential assembly of protein factors at sites of DNA damage. The efficient recognition of DNA damage and its repair are orchestrated by specific protein-protein and protein-DNA interactions within NER complexes. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17948053
DOI: 10.1038/sj.emboj.7601894
PMCID: PMC2080803

Genes

ERCC1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.PMID 17948053Read ↗

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.Semantic proximity Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.Semantic proximity Read ↗

DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.Semantic proximity Read ↗

XPA: A key scaffold for human nucleotide excision repair.Semantic proximity Read ↗

The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.Semantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

Does the XPA–FEN1 Interaction Concern to Nucleotide Excision Repair or Beyond?Semantic proximity Read ↗

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.Semantic proximity Read ↗

XPA tumor variants lead to defects in NER that sensitize cells to cisplatinSemantic proximity Read ↗

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

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