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Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle

2 May 2017

Abstract excerpt

Understanding the mechanisms of attenuation and virulence of foot-and-mouth disease virus (FMDV) in the natural host species is critical for development of next-generation countermeasures such as live-attenuated vaccines. Functional genomics analyses of FMDV have identified few virulence factors of which the leader proteinase (L pro ) is the most thoroughly investigated. Previous work from our laboratory has...

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PMID: 28464897
DOI: 10.1186/s12985-017-0758-9

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