Article
Sequence variability in viral genome non-coding regions likely contribute to observed differences in viral replication amongst MARV strains.
Virology - 25 May 2013
Alonso Jesus A, Patterson Jean L
Abstract excerpt
The Marburg viruses Musoke (MARV-Mus) and Angola (MARV-Ang) have highly similar genomic sequences. Analysis of viral replication using various assays consistently identified MARV-Ang as the faster replicating virus. Non-coding genomic regions of negative sense RNA viruses are known to play a role in viral gene expression. A comparison of the six non-coding regions using bicistronic minigenomes revealed that the...
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