Article
The Shiga toxin genotype rather than the amount of Shiga toxin or the cytotoxicity of Shiga toxin in vitro correlates with the appearance of the hemolytic uremic syndrome.
Diagnostic microbiology and infectious disease - 1 Nov 2007
Orth Dorothea, Grif Katharina, Khan Abdul B, Naim Asma, Dierich Manfred P, Würzner Reinhard
Abstract excerpt
Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and pathogenicity. The stx(2) and stx(2c) alleles were associated with high...
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