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Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks

1 Jan 2007

Abstract excerpt

BACKGROUND: Shiga toxins 1 and 2 (Stx1 and Stx2) are bacteriophage-encoded proteins that have been associated with hemorrhagic colitis, hemolytic uremic syndrome and other severe disease conditions. Stx1 and Stx2 are genetically and immunologically distinct but share the same compound toxin structure, method of entry and enzymatic function. RESULTS: Phylogenetic analysis was performed using Stx1 and Stx2 amino...

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PMID: 18053224
DOI: 10.1186/1471-2180-7-109

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