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Contribution and Interaction of Shiga Toxin Genes to Escherichia coli O157:H7 Virulence.

Toxins - 18 Oct 2019

Tarr Gillian A M, Stokowski Taryn, Shringi Smriti, Tarr Phillip I, Freedman Stephen B, Oltean Hanna N, Rabinowitz Peter M, Chui Linda

Abstract excerpt

Escherichia coli O157:H7 is the predominant cause of diarrhea-associated hemolytic uremic syndrome (HUS) worldwide. Its cardinal virulence traits are Shiga toxins, which are encoded by stx genes, the most common of which are stx1a, stx2a, and stx2c. The toxins these genes encode differ in their in vitro and experimental phenotypes, but the human population-level impact of these differences is poorly understood....

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Identifiers

PMID: 31635282
DOI: 10.3390/toxins11100607
PMCID: PMC6832461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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