Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.

Human molecular genetics - 15 Dec 2007

Ladd Paula D, Smith Leslie E, Rabaia Natalia A, Moore James M, Georges Sara A, Hansen R Scott, Hagerman Randi J, Tassone Flora, Tapscott Stephen J, Filippova Galina N

Abstract excerpt

Expansion of the polymorphic CGG repeats within the 5'-UTR of the FMR1 gene is associated with variable transcriptional regulation of FMR1. Here we report a novel gene, ASFMR1, overlapping the CGG repeat region of FMR1 and transcribed in the antisense orientation. The ASFMR1 transcript is spliced, polyadenylated and exported to the cytoplasm. Similar to FMR1, ASFMR1 is upregulated in individuals with premutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to CCCTC-Binding Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Gene Silencing

Share to Open Reading Frames

Share to RNA, Antisense

Share to Tissue Distribution

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 17921506
DOI: 10.1093/hmg/ddm293

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.PMID 17921506Read ↗

A single base alteration in the CGG repeat region of FMR1: possible effects on gene expression and phenotype.Semantic proximity Read ↗

Beyond Trinucleotide Repeat Expansion in Fragile X Syndrome: Rare Coding and Noncoding Variants in FMR1 and Associated Phenotypes.Semantic proximity Read ↗

Altered expression of the FMR1 splicing variants landscape in premutation carriers.Semantic proximity Read ↗

Spontaneous rescue of a FMR1 repeat expansion and review of deletions in the FMR1 non-coding region.Semantic proximity Read ↗

Expansion of an intermediate allele of the FMR1 gene in only two generations.Semantic proximity Read ↗

The role of AGG interruptions in the transcription of FMR1 premutation alleles.Semantic proximity Read ↗

Quantitative comparison of FMR1 gene expression in normal and premutation alleles.Semantic proximity Read ↗

CGG repeat expansion at FMR1 locus - A new molecular diagnostic algorithm in fragile X syndrome.Semantic proximity Read ↗

Examination of FMR1 transcript and protein levels among 74 premutation carriers.Semantic proximity Read ↗

Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.Semantic proximity Read ↗

CGG repeat in the FMR1 gene: size matters.Semantic proximity Read ↗

Instability of a (CGG)98 repeat in the Fmr1 promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.