Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of AGG interruptions in the transcription of FMR1 premutation alleles.

PloS one - 1 Jan 2011

Yrigollen Carolyn M, Tassone Federica, Durbin-Johnson Blythe, Tassone Flora

Abstract excerpt

Fragile X associated disorders are caused by a premutation allele in the fragile X mental retardation 1 gene (FMR1) and are hypothesized to result from the toxic effect of elevated levels of expanded FMR1 transcripts. Increased levels of FMR1 mRNA have indeed been reported in premutation carriers; however the mechanism by which expanded alleles lead to elevated levels of FMR1 mRNA in premutation carriers is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Fragile X Mental Retardation Protein
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Linear Models

Share to RNA, Messenger

Share to Transcription, Genetic

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 21818263
DOI: 10.1371/journal.pone.0021728
PMCID: PMC3139575

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of AGG interruptions in the transcription of FMR1 premutation alleles.PMID 21818263Read ↗

AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome.Semantic proximity Read ↗

Altered expression of the FMR1 splicing variants landscape in premutation carriers.Semantic proximity Read ↗

Improved Assays for AGG Interruptions in Fragile X Premutation Carriers.Semantic proximity Read ↗

Population survey of the human FMR1 CGG repeat substructure suggests biased polarity for the loss of AGG interruptions.Semantic proximity Read ↗

Quantitative comparison of FMR1 gene expression in normal and premutation alleles.Semantic proximity Read ↗

Examination of FMR1 transcript and protein levels among 74 premutation carriers.Semantic proximity Read ↗

Length of uninterrupted CGG repeats determines instability in the FMR1 gene.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

Detecting AGG Interruptions in Male and Female FMR1 Premutation Carriers by Single-Molecule Sequencing.Semantic proximity Read ↗

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.Semantic proximity Read ↗

[FMR1 PREMUTATION CARRIERS - ARE THEY REALLY ASYMPTOMATIC?]Semantic proximity Read ↗

Both cis and trans-acting genetic factors drive somatic instability in female carriers of the FMR1 premutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.